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Because ondansetron is metabolized by hepatic cytochrome P450 drug-metabolizing enzymes (CYP3A4, CYP2D6, CYP1A2 inducers or inhibitors of these enzymes may change the clearance and, hence, the half-life of ondansetron. Most reports have zofran been associated with concomitant use of serotonergic drugs (e.g., selective serotonin reuptake inhibitors (ssris serotonin and norepinephrine reuptake inhibitors (snris monoamine oxidase inhibitors, mirtazapine, fentanyl, lithium, tramadol, and intravenous methylene blue). The active ingredient in zofran tablets and zofran oral solution is ondansetron hydrochloride as the dihydrate, the racemic form of ondansetron and a selective blocking agent of the serotonin 5-HT 3 receptor type. Indication : Zofran is used to prevent nausea and vomiting due to chemotherapy treatment or surgery. Hepatobiliary Liver enzyme abnormalities. Pharmacokinetics Absorption Ondansetron is absorbed from prescription the gastrointestinal tract and undergoes some first-pass metabolism. The most common adverse reactions reported in 4 trials in adults for the prevention of nausea and vomiting associated with moderately emetogenic chemotherapy (primarily cyclophosphamide -based regimens) are shown in Table. Table 2: Pediatric Recommended Dosage Regimen for Prevention of Nausea and Vomiting Indication Dosage Regimen Moderately Emetogenic Cancer Chemotherapy 12 to 17 years of age: 8 mg administered 30 minutes before the start of chemotherapy, with a subsequent. The following adverse reactions have been reported in clinical trials of patients treated with ondansetron, the active ingredient of zofran. Quantity 123, rX Prescription Required, zofran ODT (Ondansetron rX Prescription Required, strength Quantity 4mg - prescription 10 tabs - Sourced from prescription Canada - 171.368mg - 10 tabs - Sourced from Canada - 254.37. Call your doctor prescription if you have any of these serious. In a pharmacokinetic trial of 16 epileptic patients maintained chronically on CYP3A4 inducers, carbamazepine, zofran or phenytoin, a reduction in AUC, Cmax, and t zofran of ondansetron was observed. Use dry hands to remove the tablet and place it in your mouth. 8 mg (ondansetron hydrochloride dihydrate equivalent to 8 mg of ondansetron are yellow, oval, film-coated tablets engraved with Zofran on one side and 8 on the other in bottles of 30 tablets ( NDC ). The majority of reports of serotonin syndrome related to 5-HT3 receptor antagonist use occurred in a post- anesthesia care unit or an infusion center. Zofran ODT Orally Disintegrating Tablets are offered in 4mg doses, and are white, round and plano-convex tablets debossed with aZ4 on one side. A total of 66 of patients in the ondansetron 24-mg once-a-day group, 55 zofran in the ondansetron 8-mg twice-aday group, and 55 in the ondansetron 32-mg once-a-day group, completed the 24-hour trial period with 0 emetic episodes and no rescue antiemetic medications. Multiday administration of ondansetron has been shown to slow colonic transit in healthy subjects. At this time, there is no clear evidence that ondansetron exposure in early pregnancy can cause cleft palate. Neurology Oculogyric crisis, appearing alone, as well as with other dystonic reactions. Use In Specific Populations Pregnancy Risk Summary Available data do not reliably inform the association of zofran and adverse fetal outcomes. Ondansetron was not mutagenic in standard tests for mutagenicity. If you are using this medication at home, be sure you have a health care provider teach you how to use. Steroid administration was excluded from these clinical trials. 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Specific Populations Age Geriatric Population A reduction in clearance and increase in elimination half-life are seen in patients older than 75 years compared prescription to younger subjects see Use In Specific Populations. Monitor patients to ensure adequate pain control when ondansetron is administered with tramadol. Your pharmacy can provide you with a dose-measuring device if you do not have one. If you have a personal or family history of Long QT syndrome you should tell your doctor before starting treatment with Zofran. If you have liver problems, inform your doctor before using Zofran. Do not attempt to alter or change your dose without your physicians consent. The developmental and health benefits of breastfeeding should be considered along with the mothers clinical need for zofran and any potential adverse effects on the breast fed infant prescription from zofran or from the underlying maternal condition. The maximum mean (95 upper confidence bound) difference in QTcF from placebo after baseline correction was.5 (21.8) milliseconds and.6 (7.4) milliseconds after 15minute intravenous infusions of 32 mg and 8 mg of ondansetron injection, respectively. Liver failure and death has been reported in cancer patients receiving concurrent medications, including potentially hepatotoxic cytotoxic chemotherapy and antibiotics. No overall differences in safety or effectiveness were observed between subjects 65 years of age and older and younger subjects.